Protein Synthesis and Decoding

Ribosomes are multifunctional ribonucleo-protein (RNP) complexes that translate the message of a genome into proteins which are required for all essential functions in every living cell. The decoding process during protein synthesis is an important step to provide functional proteins to the cell. Crystal structures provided some insights how the ribosome ensures the correct codon/anticodon interaction between the mRNA and the aminoacylated tRNA. To get a more detailed view of decoding we biochemically investigate this process by introducing non-natural modifications into the decoding center of the small ribosomal subunit.

 

 

Group Members

Current: Matthias Erlacher, Nina Clementi, Thomas Hoernes, Felix Kurzemann, Daniel Köstner

Former: Paul Huter, Pius Schrode, Matthias Fink