Publications

2022

Exosomal mitochondrial tRNAs and miRNAs as potential predictors of inflammation in renal proximal tubular epithelial cells
Ranches, G., Zeidler, M., Kessler, R., Hoelzl, M., Hess, M.W., Vosper, J., Perco, P., Schramek, H., Kummer, K.K., Kress, M., Krogsdam, A., Rudnicki, M., Mayer, G., Huettenhofer, A.
Mol. Ther. Nucleic Acids. 2022. 28, 794–813. https://doi.org/10.1016/j.omtn.2022.04.035

2021

2020

Intronic tRNAs of mitochondrial origin regulate constitutive and alternative splicing
Hoser, S.M., Hoffmann, A., Meindl, A., Gamper, M., Fallmann, J., Bernhart, S.H., Müller, L., Ploner, M., Misslinger, M., Kremser, L., Lindner, H., Geley, S., Schaal, H., Stadler, P.F., Huettenhofer, A.
Genome Biol. 2020. 21, 299. https://doi.org/10.1186/s13059-020-02199-6

2019

Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes
Grimm C, Hillen HS, Bedenk K, Bartuli J, Neyer S, Zhang Q, Hüttenhofer A, Erlacher M, Dienemann C, Schlosser A, Urlaub H, Böttcher B, Szalay AA, Cramer P, Fischer U.
Cell. 2019 Dec 12;179(7):1537-1550.e19. doi: 10.1016/j.cell.2019.11.024. | PMID: 31835032

Branch site bulge conformations in domain 6 determine functional sugar puckers in group II intron splicing.
Plangger R, Juen MA, Hoernes TP, Nußbaumer F, Kremser J, Strebitzer E, Klingler D, Erharter K, Tollinger M, Erlacher MD, Kreutz C:
Nucleic Acids Res. 47(2): 11430-11440, 2019. | PMID: 31665419

Eukaryotic Translation Elongation is Modulated by Single Natural Nucleotide Derivatives in the Coding Sequences of mRNAs.
Hoernes TP, Heimdörfer D, Köstner D, Faserl K, Nußbaumer F, Plangger R, Kreutz C, Lindner H, Erlacher MD.
Genes (Basel): 2019 Jan 25. |  PMID: 30691071

2018

Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions.
Hoernes TP, Faserl K, Juen MA, Kremser J, Gasser C, Fuchs E, Shi X, Siewert A, Lindner H, Kreutz C, Micura R, Joseph S, Höbartner C, Westhof E, Hüttenhofer A, Erlacher MD.
Nat Commun.: 2018 Nov 18. |  PMID: 30451861

Atomic mutagenesis of stop codon nucleotides reveals the chemical prerequisites for release factor-mediated peptide release.
Hoernes TP, Clementi N, Juen MA, Shi X, Faserl K, Willi J, Gasser C, Kreutz C, Joseph S, Lindner H, Hüttenhofer A, Erlacher MD.
PNAS.: 2018 Jan 18. |  PMID: 29298914

2017

The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution.
Safra M, Sas-Chen A, Nir R, Winkler R, Nachshon A, Bar-Yaacov D, Erlacher M, Rossmanith W, Stern-Ginossar N, Schwartz S.
Nature.: 2017 Oct 25. |  PMID: 29072297

In Vitro Selection of Cell-Internalizing DNA Aptamers in a Model System of Inflammatory Kidney Disease.
Ranches G, Lukasser M, Schramek H, Ploner A, Stasyk T, Mayer G, Mayer G, Hüttenhofer A.
Mol Ther Nucleic Acids.: 2017 Sep 15;8:198-210. |  PMID: 28918021

A novel but frequent variant in LPA KIV-2 is associated with a pronounced Lp(a) and cardiovascular risk reduction.
Coassin S, Erhart G, Weissensteiner H, Eca Guimarães de Araújo M, Lamina C, Schönherr S, Forer L, Haun M, Losso JL, Köttgen A, Schmidt K, Utermann G, Peters A, Gieger C, Strauch K, Finkenstedt A, Bale R, Zoller H, Paulweber B, Eckardt KU, Hüttenhofer A, Huber LA, Kronenberg F.
Eur Heart J.: 2017 Jun 14;38(23):1823-1831. |  PMID: 28444229

Identification of urinary exosomal noncoding RNAs as novel biomarkers in chronic kidney disease
Khurana R., Ranches G., Schafferer S., Lukasser M., Rudnicki M., Mayer G., Hüttenhofer A.
RNA.: 2017 Feb;23(2):142-152. |  PMID: 27872161

Atomic mutagenesis at the ribosomal decoding site
Schrode P., Huter P., Clementi N., Erlacher M.
RNA Biol.: 2017 Jan 2;14(1):104-112. |  PMID: 27841727

Translating the epitranscriptome
Hoernes TP., Erlacher MD.
Wiley Interdiscip Rev RNA: 2017 Jan;8(1). |  PMID: 27345446

2016

MicroRNA-Mediated Rescue of Fear Extinction Memory by miR-144-3p in Extinction-Impaired Mice
Murphy CP., Li X., Maurer V., Oberhauser M., Gstir R., Wearick-Silva LE., Viola TW., Schafferer S., Grassi-Oliveira R., Whittle N., Hüttenhofer A., Bredy TW., Singewald N.
Biol Psychiatry.: 2016 Dec 26. pii: S0006-3223(16)33155-9. |  PMID: 28104225

mRNA modifications: Dynamic regulators of gene expression?
Hoernes TP., Hüttenhofer A., Erlacher MD.
RNA Biol.: 2016 Sep;13(9):760-5. |  PMID: 27351916

Changes in the miRNA-mRNA Regulatory Network Precede Motor Symptoms in a Mouse Model of Multiple System Atrophy: Clinical Implications
Schafferer S., Khurana R., Refolo V., Venezia S., Sturm E., Piatti P., Hechenberger C., Hackl H., Kessler R., Willi M., Gstir R., Krogsdam A., Lusser A., Poewe W., Wenning GK., Hüttenhofer A., Stefanova N.
PLoS One.: 2016 Mar 10;11(3):e0150705. |  PMID: 26962858

Nucleotide modifications within bacterial mRNAs regulate their translation and are able to rewire the genetic code
Hoernes TP., Clementi N., Faserl K., Glasner H., Breuker K., Lindner H., Hüttenhofer A., Erlacher MD.
Nucleic Acids Res.: 2016 Jan 29;44(2):852-62. |  PMID: 26578598

2015

Cell-SELEX: In Vitro Selection of Synthetic Small Specific Ligands
Dickinson H., Lukasser M., Mayer G., Hüttenhofer A.,
Methods in molecular biology: 2015;1296:213-224. |  PMID: 25791604

The early days of RNomics
Hüttenhofer A.,
RNA: 2015; Apr;21(4):645-647. |  PMID: 25780174

The integrity of the G2421-C2395 base pair in the ribosomal E-site is crucial for protein synthesis
Koch M., Clementi N., Rusca N., Vögele P., Erlacher M., Polacek N.,
RNA biology: 2015 Jan 2;12(1):70-81. |  PMID: 25826414

2014

Generation of a neuro-specific microarray reveals novel differentially expressed noncoding RNAs in mouse models for neurodegenerative diseases
Gstir R., Schafferer S., Scheideler M., Misslinger M., Griehl M., Daschil N., Humpel C., Obermair GJ., Schmuckermair C., Striessnig J., Flucher BE., Hüttenhofer A.,
RNA: 2014; Dec;20(12):1929-43. |  PMID: 25344396

2013

microRNAs in nociceptive circuits as predictors of future clinical applications
Kress M1., Hüttenhofer A., Landry M., Kuner R., Favereaux A., Greenberg D., Bednarik J., Heppenstall P., Kronenberg F., Malcangio M., Rittner H., Uçeyler N., Trajanoski Z., Mouritzen P., Birklein F., Sommer C., Soreq H.,
Frontiers in Molecular Neuroscience: 2013; Oct 17;6:33. |  PMID: 24151455

2012

Expression Profiling of a Heterogeneous Population of ncRNAs Employing a Mixed DNA/LNA Microarray
Skreka K., Zywicki M., Karbiener M., Hüttenhofer A., Scheideler M., Rederstorff M.,
NUCLEIC ACIDS RESEARCH: 2012; 283560 |  PMID: 22778910

Probing functions of the ribosomal peptidyl transferase center by nucleotide analog interference
Erlacher MD., Polacek N.,
NUCLEIC ACIDS RESEARCH: 2012;848:215-226. |  PMID: 22315072

Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice
Ottina, E., Grespi, F., Tischner, D., Soratroi, C., Geley, S., Ploner, A., Reichardt, HM., Villunger, A., Herold, MJ.,
BLOOD: 2012; 119: S. 6032-6042  |   PMID: 22581448

A microchip diagnostic hybrid for the detection of noncoding RNA
Skreka, K., Rederstorff, M.,
M S-MEDECINE SCIENCES: 2012; 28: S. 819-821  |  PMID: 23067410

Identification of differentially expressed non-coding RNAs in embryonic stem cell neural differentiation
Skreka, K., Schafferer, S., Nat, IR., Zywicki, M., Salti, A., Apostolova, G., Griehl, M., Rederstorff, M., Dechant, G., Huttenhofer, A.,
NUCLEIC ACIDS RESEARCH: 2012; 40: S. 6001-6015  |  PMID: 22492625

Revealing stable processing products from ribosome-associated small RNAs by deep-sequencing data analysis
Zywicki, M., Bakowska-Zywicka, K., Polacek, N.,
NUCLEIC ACIDS RESEARCH: 2012; 40: S. 4013-4024  |  PMID: 22266655

2011

Generation of chemically engineered ribosomes for atomic mutagenesis studies on protein biosynthesis
Erlacher, MD., Chirkova, A., Voegele, P., Polacek, N.,
NATURE PROTOCOLS: 2011; 6: S. 580-592  |  PMID: 21527916

Native Chemical Ligation of Hydrolysis-Resistant 3 \’-Peptidyl-tRNA Mimics
Geiermann, AS., Polacek, N., Micura, R.,
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY: 2011; 133: S. 19068-19071  |  PMID: 22050598

The Ribosome Meets Synthetic Biology
Polacek, N.,
CHEMBIOCHEM: 2011; 12: S. 2122-2124  |  PMID: 21786379

cDNA library generation from ribonucleoprotein particles
Rederstorff, M., Huttenhofer, A.,
NATURE PROTOCOLS: 2011; 6: S. 166-174  |  PMID: 21293458

The novel RNA-methyl-transferase NOPSI modulates the life span of Drosophila melanogaster
Schosserer, M., Minois, N., Bakowska-Zywicka, K., Fuchs, E., Sekot, G., Grillari-Voglauer, R., Polacek, N., Grillari, J.,
EXPERIMENTAL GERONTOLOGY: 2011; 46: S. 209-209

The small RNA PhrS stimulates synthesis of the Pseudomonas aeruginosa quinolone signal
Sonnleitner, E., Gonzalez, N., Sorger-Domenigg, T., Heeb, S., Richter, AS., Backofen, R., Williams, P., Huttenhofer, A., Haas, D., Blasi, U.,
MOLECULAR MICROBIOLOGY: 2011; 80: S. 868-885  |  PMID: 21375594

2010

Chemically Engineered Ribosomes: A New Frontier in Synthetic Biology
Chirkova, A., Erlacher, M., Micura, R., Polacek, N.,
CURRENT ORGANIC CHEMISTRY: 2010; 14: S. 148-161

The role of the universally conserved A2450-C2063 base pair in the ribosomal peptidyl transferase center.
Chirkova, A., Erlacher, MD., Clementi, N., Zywicki, M., Aigner, M., Polacek, N.,
NUCLEIC ACIDS RESEARCH: 2010; 38: S. 4844-4855  |  PMID: 20375101

Atomic mutagenesis reveals A2660 of 23S ribosomal RNA as key to EF-G GTPase activation
Clementi, N., Chirkova, A., Puffer, B., Micura, R., Polacek, N.,
NATURE CHEMICAL BIOLOGY: 2010; 6: S. 344-351

Ribosome-associated GTPases: The role of RNA for GTPase activation.
Clementi, N., Polacek, N.,
RNA BIOLOGY: 2010; 7: S. 521-527  |  PMID: 20657179

Reliable semi-synthesis of hydrolysis-resistant 3\’-peptidyl-tRNA conjugates containing genuine tRNA modifications
Graber, D., Moroder, H., Steger, J., Trappl, K., Polacek, N., Micura, R.,
NUCLEIC ACIDS RESEARCH: 2010; 38: S. 6796-6802  |  PMID: 20525967

Somatic mutations throughout the entire mitochondrial genome are associated with elevated PSA levels in prostate cancer patients.
Kloss-Brandstätter, Anita, Schäfer, Georg, Erhart, Gertraud, Hüttenhofer, Alexander, Coassin, Stefan, Seifarth, Christof, Summerer, Monika, Bektic, Jasmin, Klocker, Helmut, Kronenberg, Florian,
AMERICAN JOURNAL OF HUMAN GENETICS: 2010; 87: S. 802-812  |  PMID: 21129724

RNPomics: Defining the ncRNA transcriptome by cDNA library generation from ribonucleo-protein particles
Rederstorff, M., Bernhart, SH., Tanzer, A., Zywicki, M., Perfler, K., Lukasser, M., Hofacker, IL., Huttenhofer, A.,
NUCLEIC ACIDS RESEARCH: 2010; 38: S. e113  |  PMID: 20150415

Small non-coding RNAs in disease development and host-pathogen interactions
Rederstorff, M., Huttenhofer, A.,
CURRENT OPINION IN MOLECULAR THERAPEUTICS: 2010; 12: S. 684-694  |  PMID: 21154160

Identification of novel ribonucleo-protein complexes from the brain-specific snoRNA MBII-52
Soeno, Y., Taya, Y., Stasyk, T., Huber, LA., Aoba, T., Huttenhofer, A.,
RNA-A PUBLICATION OF THE RNA SOCIETY: 2010; 16: S. 1293-1300  |  PMID: 20484469

Aptazyme-Mediated Regulation of 16S Ribosomal RNA
Wieland, M., Berschneider, B., Erlacher, MD., Hartig, JS.,
CHEMISTRY & BIOLOGY: 2010; 17: S. 236-242  |  PMID: 20338515

2009

Selenoprotein N is dynamically expressed during mouse development and detected early in muscle precursors
Castets, P., Maugenre, S., Gartioux, C., Rederstorff, M., Krol, A., Lescure, A., Tajbakhsh, S., Allamand, V., Guicheney, P.,
BMC DEVELOPMENTAL BIOLOGY: 2009; 9: S.

Expression and Processing of a Small Nucleolar RNA from the Epstein-Barr Virus Genome
Hutzinger, R., Feederle, R., Mrazek, J., Schiefermeier, N., Balwierz, PJ., Zavolan, M., Polacek, N., Delecluse, HJ., Huttenhofer, A.,
PLOS PATHOGENS: 2009; 5: S.   |  PMID: 19680535

Development-dependent scavenging of nucleic acids in the filamentous fungus Aspergillus fumigatus
Jochl, C., Loh, E., Ploner, A., Haas, H., Huettenhofer, A.,
RNA BIOLOGY: 2009; 6: S. 179-186  |  PMID: 19246986

Non-Hydrolyzable RNA-Peptide Conjugates: A Powerful Advance in the Synthesis of Mimics for 3 \’-Peptidyl tRNA Termini
Moroder, H., Steger, J., Graber, D., Fauster, K., Trappl, K., Marquez, V., Polacek, N., Wilson, DN., Micura, R.,
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION: 2009; 48: S. 4056-4060  |  PMID: 19396850

Epstein-Barr Virus-Induced Expression of a Novel Human Vault RNA
Nandy, C., Mrazek, J., Stoiber, H., Grasser, FA., Huttenhofer, A., Polacek, N.,
JOURNAL OF MOLECULAR BIOLOGY: 2009; 388: S. 776-784  |  PMID: 19298825

Methodological obstacles in knocking down small noncoding RNAs
Ploner, A., Ploner, C., Lukasser, M., Niederegger, H., Huttenhofer, A.,
RNA-A PUBLICATION OF THE RNA SOCIETY: 2009; 15: S. 1797-1804  |  PMID: 19690100

Glucocorticoid-regulated microRNAs and mirtrons in acute lymphoblastic leukemia
Rainer, J., Ploner, C., Jesacher, S., Ploner, A., Eduardoff, M., Mansha, M., Wasim, M., Panzer-Grumayer, R., Trajanoski, Z., Niederegger, H., Kofler, R.,
LEUKEMIA: 2009; 23: S. 746-752  |  PMID: 19148136

Evidence for Pseudoknot Formation of Class I preQ(1) Riboswitch Aptamers
Rieder, U., Lang, K., Kreutz, C., Polacek, N., Micura, R.,
CHEMBIOCHEM: 2009; 10: S. 1141-1144  |  PMID: 19382115

A novel pipeline for automated assembly and analysis of high throughput cDNA libraries
Zywicki, M.,
FEBS JOURNAL: 2009; 276: S. 398-398

2008

Ribosomal catalysis – The evolution of mechanistic concepts for peptide bond formation and peptidyl-tRNA hydrolysis
Erlacher, MD., Polacek, N.,
RNA BIOLOGY: 2008; 5: S. 5-12  |  PMID: 18388484

Small ncRNA transcriptome analysis from Aspergillus fumigatus suggests a novel mechanism for regulation of protein synthesis
Jochl, C., Rederstorff, M., Hertel, J., Stadler, PF., Hofacker, IL., Schrettl, M., Haas, H., Huttenhofer, A.,
NUCLEIC ACIDS RESEARCH: 2008; 36: S. 2677-2689  |  PMID: 18346967

The role of 23S ribosomal RNA residue A2451 in peptide bond synthesis revealed by atomic mutagenesis
Lang, K., Erlacher, M., Wilson, DN., Micura, R., Polacek, N.,
CHEMISTRY & BIOLOGY: 2008; 15: S. 485-492  |  PMID: 18439847

Identification of novel guide RNAs from the mitochondria of Trypanosome brucei
Madej, MJ., Niemann, M., Huttenhofer, A., Goringer, HU.,
RNA BIOLOGY: 2008; 5: S. 84-91  |  PMID: 18418086

Diamonds in the rough: mRNA-like non-coding RNAs
Rymarquis, LA., Kastenmayer, JP., Huttenhofer, AG., Green, PJ.,
TRENDS IN PLANT SCIENCE: 2008; 13: S. 329-334  |  PMID: 18448381

Detection of small RNAs in Pseudomonas aeruginosa by RNomics and structure-based bioinformatic tools
Sonnleitner, E., Sorger-Domenigg, T., Madej, MJ., Findeiss, S., Hackermuller, J., Huettenhofer, A., Stadler, PF., Blasi, U., Moll, I.,
MICROBIOLOGY-SGM: 2008; 154: S. 3175-3187  |   PMID: 18832323

2007

An intact ribose moiety at A2602 of 23S rRNA is key to trigger peptidyl-tRNA hydrolysis during translation termination
Amort, M., Wotzel, B., Bakowska-Zywicka, K., Erlacher, MD., Micura, R., Polacek, N.,
NUCLEIC ACIDS RESEARCH: 2007; 35: S. 5130-5140  |  PMID: 17660192

Molecular insights into substrate stereoselectivity of the ribosome
Fischer, M., Weisleitner, N., Micura, R., Polacek, N.,
FEBS JOURNAL: 2007; 274: S. 368-368

Small ncRNA transcriptome analysis from kinetoplast mitochondria of Leishmania tarentolae
Madej, MJ., Alfonzo, JD., Huttenhofer, A.,
NUCLEIC ACIDS RESEARCH: 2007; 35: S. 1544-1554  |  PMID: 17287292

Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) induces the expression of the cellular microRNA miR-146a
Motsch, N., Pfuhl, T., Mrazek, J., Barth, S., Grasser, FA.,
RNA BIOLOGY: 2007; 4: S. 131-137  |  PMID: 18347435

Subtractive hybridization identifies novel differentially expressed ncRNA species in EBV-infected human B cells
Mrazek, J., Kreutmayer, SB., Grasser, FA., Polacek, N., Huttenhofer, A.,
NUCLEIC ACIDS RESEARCH: 2007; 35: S.   |  PMID: 17478510

Probing ribosome functions by nucleotide analog interference
Polacek, N., Amort, M., Erlacher, M., Micura, R.,
FEBS JOURNAL: 2007; 274: S. 66-66

Assaying 50S assembly by a damage-selection procedure
Trappl, KM., Polacek, N.,
FEBS JOURNAL: 2007; 274: S. 368-368

Anopheles gambiae miRNAs as actors of defence reaction against Plasmodium invasion
Winter, F., Edaye, S., Huttenhofer, A., Brunel, C.,
NUCLEIC ACIDS RESEARCH: 2007; 35: S. 6953-6962  |  PMID: 17933784

2006

Efficient ribosomal peptidyl transfer critically relies on the presence of the ribose 2 \’-OH at A2451 of 23S rRNA
Erlacher, MD., Lang, K., Wotzel, B., Rieder, R., Micura, R., Polacek, N.,
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY: 2006; 128: S. 4453  |  PMID: 16569023

RNomics: Identification and function of small non-protein-coding RNAs in model organisms
Huttenhofer, A.,
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY: 2006; 71: S. 135-140 604  |  PMID: 17381289

The principles of guiding by RNA: chimeric RNA-protein enzymes
Huttenhofer, A., Schattner, P.,
NATURE REVIEWS GENETICS: 2006; 7: S. 475-482  |  PMID: 16622413

Experimental approaches to identify non-coding RNAs
Huttenhofer, A., Vogel, J.,
NUCLEIC ACIDS RESEARCH: 2006; 34: S. 635-646  |  PMID: 16436800

Identification of small non-coding RNAs from mitochondria and chloroplasts
Lung, B., Zemann, A., Madej, MJ., Schuelke, M., Techritz, S., Ruf, S., Bock, R., Huttenhofer, A.,
NUCLEIC ACIDS RESEARCH: 2006; 34: S. 3842-3852  |  PMID: 16899451

The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosorne
Qin, Y., Polacek, N., Vesper, O., Staub, E., Einfeldt, E., Wilson, DN., Nierhaus, KH.,
CELL: 2006; 127: S. 721-733  |  PMID: 17110332

2005

Chemical engineering of the peptidyl transferase center reveals an important role of the 2 \’-hydroxyl group of A2451
Erlacher, MD., Lang, K., Shankaran, N., Wotzel, B., Huttenhofer, A., Micura, R., Mankin, AS., Polacek, N.,
NUCLEIC ACIDS RESEARCH: 2005; 33: S. 1618-1627  |  PMID: 15767286

Non-coding RNAs: hope or hype?
Huttenhofer, A., Schattner, P., Polacek, N.,
TRENDS IN GENETICS: 2005; 21: S. 289-297  |  PMID: 15851066

The ribosomal peptidyl transferase center: Structure, function, evolution, inhibition
Polacek, N., Mankin, AS.,
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY: 2005; 40: S. 285-311  |  PMID: 16257828

Identification of novel non-coding RNAs as potential antisense regulators in the archaeon Sulfolobus solfataricus
Tang, TH., Polacek, N., Zywicki, M., Huber, H., Brugger, K., Garrett, R., Bachellerie, JP., Huttenhofer, A.,
MOLECULAR MICROBIOLOGY: 2005; 55: S. 469-481  |  PMID: 15659164

ADAR2-mediated editing of RNA substrates in the nucleolus is inhibited by C/D small nucleolar RNAs
Vitali, P., Basyuk, E., Le Meur, E., Bertrand, E., Muscatelli, F., Cavaille, J., Huttenhofer, A.,
JOURNAL OF CELL BIOLOGY: 2005; 169: S. 745-753  |  PMID: 15939761

Mapping of conserved RNA secondary structures predicts thousands of functional noncoding RNAs in the human genome
Washietl, S., Hofacker, IL., Lukasser, M., Huttenhofer, A., Stadler, PF.,
NATURE BIOTECHNOLOGY: 2005; 23: S. 1383-1390  |  PMID: 16273071

Experimental RNomics in Aquifex aeolicus: identification of small non-coding RNAs and the putative 6S RNA homolog
Willkomm, DK., Minnerup, J., Huttenhofer, A., Hartmann, RK.,
NUCLEIC ACIDS RESEARCH: 2005; 33: S. 1949-1960  |  PMID: 15814812

2003

Plant snoRNA database
Brown, JW. S., Echeverria, M., Qu, LH., Lowe, TM., Bachellerie, JP., Huttenhofer, A., Kastenmayer, JP., Green, PJ., Shaw, P., Marshall, DF.,
NUCLEIC ACIDS RESEARCH: 2003; 31: S. 432  |  PMID: 12520043

The critical role of the universally conserved A2602 of 23S ribosomal RNA in the release of the nascent peptide during translation termination
Polacek, N., Gomez, MJ., Ito, K., Xiong, LQ., Nakamura, Y., Mankin, A.,
MOLECULAR CELL: 2003; 11: S. 103  |  PMID: 12535525

Binding of L7Ae protein to the K-turn of archaeal snoRNAs: a shared RNA binding motif for C/D and H/ACA box snoRNAs in Archaea
Rozhdestvensky, TS., Tang, TH., Tchirkova, IV., Brosius, J., Bachellerie, JP., Huttenhofer, A.,
NUCLEIC ACIDS RESEARCH: 2003; 31: S. 869  |  PMID: 12560482

Identification Of 13 Novel Human Modification Guide Rnas
Vitali, P., Royo, H., Seitz, H., Bachellerie, JP., Huttenhofer, A., Cavaille, J.,
NUCLEIC ACIDS RESEARCH: 2003; 31: S. 6543-6551  |  PMID: 14602913

Rnomics In Escherichia Coli Detects New Srna Species And Indicates Parallel Transcriptional Output In Bacteria
Vogel, J., Bartels, V., Tang, TH., Churakov, G., Slagter-Jager, JG., Huttenhofer, A., Wagner, EG. H.,
NUCLEIC ACIDS RESEARCH: 2003; 31: S. 6435-6443  |  PMID: 14602901

Rnomics In Drosophila Melanogaster: Identification Of 66 Candidates For Novel Non-Messenger Rnas
Yuan, GZ., Klambt, C., Bachellerie, JP., Brosius, J., Huttenhofer, A.,
NUCLEIC ACIDS RESEARCH: 2003; 31: S. 2495-2507  |  PMID: 12736298

2002

The expanding snoRNA world
Bachellerie, JP., Cavaille, J., Huttenhofer, A.,
BIOCHIMIE: 2002; 84: S. 775  |  PMID: 12457565

Molecular aspects of the ribosomal peptidyl transferase
Dorner, S., Polacek, N., Schulmeister, U., Panuschka, C., Barta, A.,
BIOCHEMICAL SOCIETY TRANSACTIONS: 2002; 30: S. 1131  |  PMID: 12440989

RNomics: identification and function of small, non-messenger RNAs
Huttenhofer, A., Brosius, J., Bachellerie, JP.,
CURRENT OPINION IN CHEMICAL BIOLOGY: 2002; 6: S. 835  |  PMID: 12470739

Experimental RNomics: Identification of 140 candidates for small non-messenger RNAs in the plant Arabidopsis thaliana
Marker, C., Zemann, A., Terhorst, T., Kiefmann, M., Kastenmayer, JP., Green, P., Bachellerie, JP., Brosius, J., Huttenhofer, A.,
CURRENT BIOLOGY: 2002; 12: S. 2002  |  PMID: 12477388

Poly(A)-binding protein is associated with neuronal BC1 and BC200 ribonucleoprotein particles
Muddashetty, RS., Khanam, T., Kondrashov, A., Bundman, M., Iacoangeli, A., Kremerskothen, J., Duning, K., Barnekow, A., Huttenhofer, A., Tiedge, H., Brosius, J.,
JOURNAL OF MOLECULAR BIOLOGY: 2002; 321: S. 433  |  PMID:12162957

SPARK – A novel method to monitor ribosomal peptidyl transferase activity
Polacek, N., Swaney, S., Shinabarger, D., Mankin, AS.,
BIOCHEMISTRY: 2002; 41: S. 11602  |  PMID:12269803

Identification of 86 candidates for small non-messenger RNAs from the archaeon Archaeoglobus fulgidus
Tang, TH., Bachellerie, JP., Rozhdestvensky, T., Bortolin, ML., Huber, H., Drungowski, M., Elge, T., Brosius, J., Huttenhofer, A.,
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA: 2002; 99: S. 7536  |  PMID:12032318

RNomics in Archaea reveals a further link between splicing of archaeal introns and rRNA processing
Tang, TH., Rozhdestvensky, TS., d\’Orval, BC., Bortolin, ML., Huber, H., Charpentier, B., Branlant, C., Bachellerie, JP., Brosius, J., Huttenhofer, A.,
NUCLEIC ACIDS RESEARCH: 2002; 30: S. 921  |  PMID:11842103 

2001

A novel brain-specific box C/D small nucleolar RNA processed from tandemly repeated introns of a noncoding RNA gene in rats
Cavaille, J., Vitali, P., Basyuk, E., Huttenhofer, A., Bachellerie, JP.,
JOURNAL OF BIOLOGICAL CHEMISTRY: 2001; 276: S. 26374  |  PMID: 11346658

Polymorphisms at the 5-HT2C-receptor gene locus and panic disorder
Deckert, JR. G., Terhoerst, T., Dordelmann, C., Pecuch, P., Huttenhofer, A., Brosius, J., Arolt, V.,
AMERICAN JOURNAL OF MEDICAL GENETICS: 2001; 105: S. 638

RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse
Huttenhofer, A., Kiefmann, M., Meier-Ewert, S., O\’Brien, J., Lehrach, H., Bachellerie, JP., Brosius, J.,
EMBO JOURNAL: 2001; 20: S. 2943  |  PMID: 11387227

Blocking effects of the antiarrhythmic drug propafenone on the HERG potassium channel
Mergenthaler, J., Haverkamp, W., Huttenhofer, A., Skryabin, BV., Musshoff, U., Borggrefe, M., Speckmann, EJ., Breithardt, G., Madeja, M.,
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY: 2001; 363: S. 472  |   PMID: 11330342

Ribosomal peptidyl transferase can withstand mutations at the putative catalytic nucleotide
Polacek, N., Gaynor, M., Yassin, A., Mankin, AS.,
NATURE: 2001; 411: S. 498  |  PMID:11373685

Neuronal BC1 RNA structure: Evolutionary conversion of a tRNA(Ala) domain into an extended stem-loop structure
Rozhdestvensky, TS., Kopylov, AM., Brosius, J., Huttenhofer, A.,
RNA-A PUBLICATION OF THE RNA SOCIETY: 2001; 7: S. 722 |  PMID:11350036

The IC-SNURF-SNRPN transcript serves as a host for multiple small nucleolar RNA species and as an antisense RNA for UBE3A
Runte, M., Huttenhofer, A., Gross, S., Kiefmann, M., Horsthemke, B., Buiting, K.,
HUMAN MOLECULAR GENETICS: 2001; 10: S. 2687 |  PMID:11726556

A translocation breakpoint cluster disrupts the newly defined 3 \’ end of the SNURF-SNRPN transcription unit on chromosome 15
Wirth, J., Back, E., Huttenhofer, A., Nothwang, HG., Lich, C., Gross, S., Menzel, C., Schinzel, A., Kioschis, P., Tommerup, N., Ropers, HH., Horsthemke, B., Buiting, K.,
HUMAN MOLECULAR GENETICS: 2001; 10: S. 201 |  PMID: 11159938 

pKa of adenine 2451 in the ribosomal peptidyl transferase center remains elusive
Xiong, LQ., Polacek, N., Sander, P., Bottger, EC., Mankin, A.,
RNA-A PUBLICATION OF THE RNA SOCIETY: 2001; 7: S. 1365-1369  |  PMID: 11680840

2000

Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization
Cavaille, J., Buiting, K., Kiefmann, M., Lalande, M., Brannan, CI., Horsthemke, B., Bachellerie, JP., Brosius, J., Huttenhofer, A.,
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA: 2000; 97: S. 14311 | PMID: 11106375 

Identification of imprinted, tissue-specific C/D box small nucleolar RNA genes in the Prader-Willi syndrome region
Huettenhofer, AG., Cavaille, J., Buiting, K., Kiefman, M., Lalande, M., Brannan, CI., Horsthemke, B., Bachellerie, JP., Brosius, J.,
AMERICAN JOURNAL OF HUMAN GENETICS: 2000; 67: S. 28

Periodic conformational changes in rRNA: Monitoring the dynamics of translating ribosomes
Polacek, N., Patzke, S., Nierhaus, KH., Barta, A.,
MOLECULAR CELL: 2000; 6: S. 159 | PMID: 10949037 

In vitro selection of RNA aptamers that bind special elongation factor SelB, a protein with multiple RNA-binding sites, reveals one major interaction domain at the carboxyl terminus
Klug, SJ., Huttenhofer, A., Famulok, M.,
RNA-A PUBLICATION OF THE RNA SOCIETY: 1999; 5: S. 1180 | PMID: 10496219

Selenocysteine inserting RNA elements modulate GTP hydrolysis of elongation factor SelB
Huttenhofer, A., Bock, A.,
BIOCHEMISTRY: 1998; 37: S. 885 | PMID: 9454578

In vitro and in vivo characterization of novel mRNA motifs that bind special elongation factor SelB
Klug, SJ., Huttenhofer, A., Kromayer, M., Famulok, M.,
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA: 1997; 94: S. 6676 |  PMID: 9192624